Tag: science

Ketogenic diets are well established in medicine as interventions that effectively control epileptic seizures in children. However, their popularity for weight loss has skyrocketed in the past few years. A Google Trends search from the years 2004 to 2019 clearly shows the increased interest in the diets. However, the question remains, does the ketogenic diet…
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Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEA-S) are the most abundant circulating steroid hormones in humans.  However, the molecular, cellular, and physiological mechanism of its action and relationship to human health are not yet fully known.  What is known, however, is that large amounts of DHEA are produced during fetal development, but after birth, this…
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In medicine, an adverse effect is an undesired, harmful effect that is the result of a medication, surgery, diet, or other intervention. The ketogenic diet has grown significantly in popularity over the past few years, and while the Ketogenic Diet has numerous benefits supported by science, there are other potential adverse of effects of the Ketogenic Diet that warrant…
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Over the past few years, many diet regimens have been studied for efficacy in improving the symptoms of patients with autism spectrum disorder (ASD).  The gluten free casein free diet (GFCF) is a popular diet that has been used for ameliorating gastrointestinal manifestations of ASD such as bloating, diarrhea, and discomfort that often occurs in autistic…
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 Ketogenic Diet Research 2019 TABLE OF CONTENTS         RANDOMIZED CONTROLLED TRIALS  •  Diabetes •  Weight Loss •  Cancer •  Epilepsy •  Safety •  Autism •  Exercise •  Global Development Delay •  Metabolism •  Cardiovascular Risk •  Infantile Spasms •  Metabolism   META-ANALYSIS •  Weight Loss •  Epilepsy SYSTEMATIC REVIEWS •  Weight Loss…
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First used in the 1920s, the ketogenic diet is most known for its established efficacy in treating intractable epilepsy and is best known clinically for this role.  The mechanisms of the ketogenic diet are complex and not fully understood.  Though, it likely involves metabolic adaptation in cellular signaling pathways, decreased neuronal excitability, and neuroprotection.  As such,…
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Since the time of Hippocrates, it has been known that by fasting one could significantly alter the course of some diseases like epilepsy.  While the mechanism was not initially understood, modern investigations revealed that through fasting—and the subsequent production of ketone bodies, or ketones—  other disorders including GLUT1 deficiency, and perhaps even the devastating and fatal disease Amyotrophic…
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First used in the 1920s, the ketogenic diet is most known for its established efficacy in treating intractable epilepsy and is best known clinically for this role.  The mechanisms of the ketogenic diet are complex and not fully understood.  Though, it likely involves metabolic adaptation in cellular signaling pathways, decreased neuronal excitability, and neuroprotection.  As…
Read more

Glucose is an essential source of energy for the brain.  However, glucose is polar and cannot diffuse across the blood-brain barrier. In order to enter the cell, it must be transported across the membrane through a specific transporter.  In a family of glucose transporters, one major protein transports glucose across the blood-brain barrier:  the facilitated…
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